Dr. Stephen Holt, M.D. is a Distinguished Professor of Medicine and a medical practitioner in New York State.
He has published many peer-review papers in medicine and he is a best-selling author with twenty books in
national and international distribution. He has received several awards for teaching and research. As a full
professor of medicine for 20 years and an adjunct professor of Bioengineering for 10 years. Dr. Holt is a
frequent lecturer at scientific meetings and healthcare facilities throughout the world.

ABBREVIATED CURRICULUM VITAE
STEPHEN HOLT, MD, LLD(Hon.) ChB., PhD, DNM, FRCP (C)
MRCP (UK), FACP, FACG, FACN, FACAM, OSJ
KNIGHT OF THE ORDER OF ST. JOHN

CURRENT APPOINTMENTS
Chairman Department of Integrative Medicine, NYCPM, NY
Consultant Physician in Gastroenterology, Medicine and Nutrition, New York
Founder, Wellness Publishing
Founder, Natures Benefit Inc.
Board of Trustees, NYCPM, NY
Distinguished Professor of Medicine, NYCPM
EDUCATION
Honors Graduate 1972, Liverpool University Medical school, Eng1and, UK
Postgraduate Training Internal Medicine and Gastroenterology, Therapeutics and Clinical Pharmacology,
University of Edinburgh, Scotland
Board Certified Internist and Sub specialist in USA, UK, Economic Union and Canada
HONORS
Honorary Doctorate of Humane Letters New York, USA
Congressional Medal of Distinction 2006, National Republican Congressional Committee
Several Awards for Teaching
Distinguished Chair of Medicine
RESEARCH
Nutrition, Gastrointestinal Disease and Therapeutics.
PUBLICATIONS
Author or co-author – 20 books and 500 scientific communications, with thousands of citations in
consumer or trade press articles.
SOCIAL
Born 3 May 1950, Manchester, UK.; 6 children. Children: Fraser, Stephanie, Andrew, Stephen Jr., Sophia, Evan

Stephen Holt, M.D. LLD(Hon.), ChB., DNM, FRCP (C)
MRCP (UK), FACP, FACG, FACN, FACAM, OSJ

HOME ADDRESS: 34 Crestview Road
Mountain Lakes, New Jersey 07046
Tel. 973-402-8410

BUSINESS ADDRESS: Holt Institute of Medicine
Little Falls, NJ 07103
Tel. 973-890-2378
Fax. 973-890-8654
E-Mail info@naturesbenefit.com

MEDICAL OFFICE ADDRESS:
Holt Clinic
One Rockefeller Plaza
14 West 49th St., Suite 1401
Tel. (212) 582-1700

CURRENT APPOINTMENTS:
President and CEO, Natures Benefit Inc. and Wellness Publishing Inc.
Independent Consultant to Pharmaceutical and Dietary Supplement Industry.
Private Medical Practitioner, New York
Distinguished Professor of Medicine, NYCPM, NY and Adjunct Professor Bioengineering,
New Jersey Institute of Technology, Newark, NJ

MEDICAL SCHOOL:
1972 Liverpool University Medical School, United Kingdom
MBChB with Honors, M.D. by Thesis

POSTDOCTORAL TRAINING:
Sept. 1972 - July 1976
Intern and Resident (House Officer - Registrar)
Liverpool Area Health Authority Teaching Hospitals,
Liverpool, United Kingdom

July 1976 - Jan. 1981
Lecturer in Medicine, Therapeutics and Clinical Pharmacology, Senior Registrar in Medicine
Department of Therapeutics and Clinical Pharmacology, University of Edinburgh and The Edinburgh
Royal Infirmary, Scotland (including research sabbatical 1979-1980 at the Addiction Research
Foundation of Ontario, Toronto, Canada)

LICENSURE:
Sept. 4, 1973 General Medical Council, UK Reg. No1552670
Dec. 29, 1993 New York State Education Department, License No. 194529

CERTIFICATION BY EXAMINATION (TRAINING):
1982/87 Sub-Specialty Board: Diplomate, American Board of Internal Medicine, Subspecialty
Gastroenterology, No. 84644, 11/10/87
1982 Specialty Board: Diplomate, Internal Medicine, American Board of Internal Medicine
No. 84644, 09/15/83
1975 Member, Royal College of Physicians, United Kingdom,
(MRCP UK) 1975.
1979/84 Joint Committee on Higher Medical Training Certification
in Internal Medicine and Gastroenterology UK (1984)
1980 Licentiate of the Medical Council of Canada (LMCC) 1981.
1980 Fellow, Royal College of Physicians of Canada, Internal Medicine, FRCP (C) 1981.
1980 Fellow, Royal College of Physicians of Canada, Gastroenterology, FRCP (C) 1981.
1982 VQE, National Board of Medical Examiners 1981.
1982 FLEX, Federal Licensing Examination 1981.

BY ELECTION:
1983 Fellow, American College of Physicians, (FACP)
1985 Fellow, American College of Gastroenterology, (FACG)
1986 Fellow, American College of Nutrition,(FACN)
2003 Fellow, American College of Advancement of Medicine (FACAM)

BY THESIS:
1993 Doctor of Medicine "Measurements of Gastric Emptying
Rate in Humans"
2006 Doctor of Natural Medicine, Pan-American Institute of Natural Medicine, Nevis, WI

BY PEER REGOGNITION:
2006 By Investiture, Knight of Grace, Holy Order of Knights of St. John (OSJ)
2005 Doctor of Humane Letters, NYCPM, New York, USA, 2005
2006 Congressional Medal of Distinction 2006, National Republican Congressional Committee
2006 NRCC, Republican Businessman of the Year, NJ

UNIVERSITY APPOINTMENTS:
2006 - Current Distinguished Professor of Medicine, New York College Podiatric Medicine, NYCPM
1998 - Current William Paul Haber, Professor of Medicine and President Illinois College of
Physicians and Surgeons, Professor of Medicine, Capital University of Integrative Medicine,
Washington, DC, Adjunct Professor of Bioengineering, New Jersey Institute of Technology, Newark, NJ.
1991-2000: Clinical Professor of Medicine
Seton Hall University

January 1989 - September 1991
Professor of Medicine
Division of Gastroenterology
University of South Carolina
Columbia, SC, USA
February 1986 - January 1989
Professor of Medicine
Division of Gastroenterology
Southern Illinois University
School of Medicine
Springfield, Illinois, USA
Director, SIU Diagnostic Labs
January 1984 - February 1986
Associate Professor of Medicine
Case Western Reserve University
Cleveland, Ohio, USA
January 1981 - January 1984 Research Positions:
W.W. Cross Cancer Institute and
University of Saskatchewan
Canada

HOSPITAL APPOINTMENT:
July 1972 – January 1981 Training grade hospital appointments in continuity
January 1981 – January 1984 Research appointments
January 1984 – February 1986 Cleveland Metropolitan General Hospital– attending
Gastroenterologist
February 1986 – January 1989 Memorial Medical Center, Springfield, IL
January 1989 – September 1991 Richland Memorial Hospital, Columbia, SC
September 1991 – January 1994 Montclair Community Hospital, Cathedral Healthcare
January 1994 – 1996 Long Island College Hospital
January 1996 - current Private Practice, NY, with academic affiliations, NYCPM

PAST HONORARY APPOINTMENTS:
• Visiting Professor of Medicine Sun Yat Sen University of Medical Sciences Canton, China 1986
• Adjunct Professor University of New England College of Osteopathic Medicine 1991

VISITING APPOINTMENTS:
By invitation, I have been a visiting professor and delivered lectures at several institutions or
affiliated societies worldwide, including, but not limited to:

BUSINESS HONOR:
Chairman, Business Advisory
Council of Republican Party (NRCC) New Jersey. Current, 2006

SCHOLARSHIPS:
1978 British Council, Young Research Workers Award
1979 Carnegie Trust for the Universities of Scotland
EDITORIAL BOARDS:
1988-90 Current Opinion in Gastroenterology, Current Science, UK (Editor)
1989-92 Current Issues in Gastrointestinal Motility ad hoc
1991-93 Practical Gastroenterology ad hoc
1993-93 Modern Medicine ad hoc
1995-00 Regular Feature Article (Journal of Alternative and Complementary Medicine)
1996-00 Natural Pharmacy
1999-00 Natural Medicine
1995 – current Ad hoc several journals
REVIEWER OF SCIENTIFIC ARTICLES:

MAJOR COMMITTEE ASSIGNMENTS:
National Committees:
1987 - 1989 Educational Affairs, American College of Gastroenterology
1986 - 1988 Advisory Panel DATTA American Medical Association
1987 - 1988 Institute of Medicine of Washington, Task Force on Assessment and Treatment Assignment,
Advisory Committee reporting to the U.S. Congress, contributor to IOM target objectives for health
care in the 1990’s.
1987 - 1989 Regional and National CME Planning, American College of Gastroenterology
1989 - 1992 International Relations Committee, American College of Gastroenterology
2000-current Funding Committee: Illinois College of Physicians and Surgeons
2006 Honorary President, Republican Business Advisory Council, NJ
Committees,
Institutional:
I have served on, or chaired, several different types of institutional committees including, ethics, tenure,
teaching, planning, institutional liaison, data review, salaries and promotions, clinical services, nutrition,
medical education, laser, oncology and research policy and advisory committees. As the President
of the Illinois College of Physicians and surgeons, I am responsible for the appointment of all faculty
to the new medical school. Faculty evaluation and recruitment at NYCPM.

MEMBERSHIPS IN SOCIETIES:
* The American Gastroenterology Association
The British Society of Gastroenterology
* The American College of Gastroenterology
The American Society of Nuclear Medicine
Collegiate Member of the Royal College of Physicians (UK)
* The Royal College of Physicians and Surgeons of Canada
The British Medical Association
New York Academy of Sciences
* The American College of Nutrition
The Pan American Medical Association
The American Society of Parenteral and Enteral Nutrition
* The American Society of Internal Medicine
The American Federation of Clinical Research
The American Medical Association
* denotes current

RESEARCH INTERESTSAND EXPERIENCE:
I have performed independent and collaborative research in the following areas: bioengineering,
epidemiology, gastrointestinal function, therapeutics, nutrition and drug development. I have
special interests in new drug development, phase I-V, pharmaceutical and biotechnology with
special interests in remedies of natural origin.

GRANT HISTORY:
I have held grants (principal or co-investigator) from American Cancer Society, Ontario Government,
co-investigator Federal Government Special-Fund-Ionising Radiation, Canada, 1983 Local
Foundations and Industry. (1972-94) >5 million and much industry funding of research, including
key decisions on drug and supplement research and development. Advice and administration of
large commercial budgets in medical research, > 60 million per annum, on occasion.

MAJOR TEACHING EXPERIENCE:
Undergraduate:
I have organized and delivered undergraduate teaching in Therapeutics, Pharmacy Clinical
Pharmacology, Advanced Nursing Studies, Gastroenterology and Nutrition, which included
responsibilities in basic science and clinical education. I have general internal medicine and physical
diagnosis, ad hoc. Since 1975, I have been involved in core program teaching in medicine, dentistry
and pharmacy and planned curricula and revision for several Academic Institutions. I have been
active in planning undergraduate curriculae. I have contributed to the design of graduate programs in
medical sciences.

Graduate:
I have been actively involved in the organization and delivery of residency and fellowship teaching.
The programs emphasized continuing assessment and board preparation. I was a principal teacher
for MRCP diploma examinations and taught physicians from several European countries, the Far
East and India for the membership examinations of the Royal College of Physicians (UK). I was an
instructor for the diploma in Advanced Nursing, UK, and was a Royal College of Nursing examiner.
I was a co-founder of the Self Assessment Program in Gastroenterology that is used by the American
College of Gastroenterology. I have run ACGME accredited Gastroenterology programs and have
restored one program from cancellation by ACGME and two programs from probation to full accreditation.
I have supervised or contributed to achievements of several thesis candidates.

Other:
I have chaired or contributed to the organization and delivery of several regional, national and
international continuing medical education symposia including affiliations with the European
Society of Digestive Diseases, American College of Gastroenterology, the World Congress of
Gastroenterology and the Asian-Pacific Congress of Gastroenterology and the Asian-Pacific Congress
of Digestive Endoscopy. I was the Director of the Sino-American Education and Research Exchange
with Sun Yat-Sen University in China, where I hold an honorary faculty appointment. My fellows have won
regional awards and national citations from the American College of Physicians for research. I have
planned seminars on dietary supplements research and regulatory issues. I am regular keynote
speaker at national and international food science meetings. I have special interests in alternative
medical practices as a complementary approach to medicine.

PRINCIPAL CLINICAL AND HOSPITAL SERVICE RESPONSIBILITIES:
I have received training in each subspecialty of Internal Medicine. I have broad experience of administrative
matters in hospital and academic practice. I am experienced in all diagnostic and therapeutic endoscopic
procedures. I have always taken full clinical service responsibilities. My duties have included medical
outpatient clinics, impatient consultations, all endoscopic procedures and administrative responsibilities.
Patient Care has been integrated with undergraduate and postgraduate teaching of medical students,
residents and fellows. My practice is largely tertiary referral. I have headed Quality Assurance programs
and consulted with several third party insurance agencies.

MAJOR ADMINISTRATIVE RESPONSIBILITIES:
- Chair Task Force Committees on health care delivery in University and Community Hospital settings.
- Medical Education and Research Policy development and implementation.
- Medical Research organization contract services, fiscal arrangements.
- Staff recruitment and development including physicians, nursing, ancillary professionals.
- Institute of Medicine, Washington advisory role to US Congress, Reagan Administration.

MEDICAL COMMUNICATIONS:
- Ambulatory Care, special services organization.
- Bylaws, Q.A. Policy Administration and Leadership.
- Management consulting in the health care industry, government at county, state and national level.
PRACTICE:
I have maintained the practice of internal medicine, nutrition and gastroenterology throughout my
entire career.

PROFESSIONAL WRITING (ASSIGNMENTS, REGULAR AND AD HOC:
Natural Pharmacy
Great Life Magazine
Muscle Fitness
Current Perspectives
New York Life Magazine
In Practice
Vitamin Retailer
Whole Foods Magazine
Natural Medicine
Alternative and Complementary Therapies
Let’s Live
Ad hoc: for trade, industry, supply and peer review journals, etc.

TELEMEDICINE AND TELECARE EXPERIENCE
I have been very active in the development and evaluation of novel health communication utilizing
creative audiovisual techniques, video presentations (pre-recorded and live), radio interviewing,
audio teaching and computer software.
I have worked with the design and application of computer assisted testing of lifestyle.
I have a special interest in computer video formats and potential interventions in health care
including epidemiological applications and patient care.
I have developed several novel communication programs for multinational pharmaceutical
companies for use in the switch of prescription drugs to over the counter formulations.
I have written or developed print and electronic teaching formats for nutritional approaches to
disease and the use of dietary supplements.

PRODUCT DEVELOPMENT (DISCLOSURE)
I have developed more than 50 biopharmaceutical or nutritional products from which I receive
royalties on sales. The cumulative sales of such products are among industry leaders in their
categories. I founded Biotherapies Inc. in 1997 and Natures benefit Inc. in 2000.

NATURES BENEFIT INC.
This corporation develops, markets and sells veterinary and human nutritional, botanical and
herbal products.

WELLNESS PUBLISHING INC.
A multimedia and book or magazine publishing company focused on popular consumer health
care issues. Expanding into areas of multimedia edutherapies.

NATURAL CLINICIAN LLC.
Research, development, and sale of food and dietary supplements to healthcare professionals

NOTE: Not all publications are listed. Focus is on peer-review publications in medical literature

PATENTS: INFORMATION UPON REQUEST (Five patent filings)

BOOKS:
Skinner HA, Holt S. The Alcohol Clinical Index. Strategies for Identifying Patients with Alcohol
Problems. Published and marketed by the Addiction Research Foundation of Ontario, 1987.
This manual is accompanied by data acquisition instruments.
Holt S, “Soya for Health” Mary Ann Liebert Publishers Inc., Larchmont, New York, June, 1996.
Holt S, “Miracle Herbs”, with Linda Comac, Birch Lane Press, Carol Publishing, Secaucus, NJ, 1998.
Barilla J., Holt S “Andrographis Paniculata”, Keats Publishing NTC Press, 1999.
Holt S, Gagliardi G, Fuerst M. “The Shark Cartilage Alternative for Bone and Joint Health”, Keats
Publishing, 1997
Holt S, “The Natural Way to a Healthy Heart, M. Evans Inc., NY, NY, 1999.
Holt S, “Natural Ways to Digestive Health”, M. Evans Inc., NY, NY, 2000.
Holt S, “The Soy Revolution”, M. Evans, NY, NY, 1998 and Dell Publishing, Random House, 2000.
Holt S, Barilla J. “The Power of Cartilage” Kensington Publishing Inc., (Zebra Books), NY, NY, 1998.
Holt S, “Natures Benefit from Coral Calcium” Second edition, Wellness Publishing, Newark, NJ, 2003.
Holt S, “The Antiporosis Plan” Wellness Publishing, Newark, NJ, 2002.
Holt S, “Combat Syndrome X, Y and Z…”, Wellness Publishing, Newark, NJ 2002.
Holt S, “Natural Digestion”, Wellness Publishing, Newark NJ, 2006
Holt S, Wright J, “Syndrome X Nutritional Factors”, Wellness Publishing, Newark NJ, 2004
Holt S, “The MenoPlan”, Wellness Publishing, Newark, NJ, 2006
Holt S, “Enhancing Low Carb Diets”, Wellness Publishing, Newark, NJ 2004
Holt S, “Sleep Naturally”, Wellness Publishing, Newark, NJ 2003
Holt S, “Supreme Properties of Hoodia Gordonii”, Wellness Publishing, Newark, NJ 2005
Holt S, “Sex Naturally”, Wellness Publishing, Little Falls, NJ 2006
Holt S, “Holt MD Labs”, Wellness Publishing, Little Falls, NJ 2006

CHAPTERS IN BOOKS ETC.:
Many co-authorships in teaching texts.
Holt S, three chapters in Upper Digestive Surgical Textbook edited by T.V. Taylor M.D., 2000.

VIDEOS:
A large number of video presentations in education and commerce.

TELEVISON:
Media expert on health matters with a focus on food, dietary supplements and natural medicine,
with appearances on many national TV broadcasts e.g. NBC, ABC, etc.

RADIO:
Extensive: top national radio guest and independent show host

MEDICAL PUBLICATIONS: NOTE: ALL TRADE, TEACHING ARTICLES NOT INCLUDED

Eastmond CJ, Holt S. A case of acute mercury vapour poisoning. Postgraduate Medical Journal
51:428-430, 1975.
Gosh P, Holt S. Tabes Dorsalis with sudden onset of paraplegia. British Journal of Venereal Diseases
51:349-351, 1975.
Holt S, Hudgins D, Krishnan KR, Critchley EMR. Diffuse myelitis associated with rubella vaccination.
British Medical Journal 2:1037-1038, 1976.
Holt S, Kirkham N. Cytomegalovirus induced haemolytic anaemia after cardiac surgery. Thorax
31:788-789, 1976.
Holt S, Kirkham N, Myerscough EM. Haemothorax after subclavian vein annulation. Thorax
32:101- 103, 1977.
Holt S. Syphilitic ostial occlusion. British Heart Journal 39:469-470, 1977.
Holt S, Ryan WF, Epstein EJ. Severe mycoplasma pneumonia. Thorax 32:112-115, 1977.
Holt S, Khan MM, Charles RG, Epstein EJ. Polyradiculoneuritis and Mycoplasma pneumoniae infection.
Postgraduate Medical Journal 53(621):416-8, 1977.
Holt S, Myerscough EM. Pneumothorax and hydrothorax after subclavian vein cannulation. Postgraduate
Medical Journal (April 1977) 53, 226-227.
Holt S, Hicks DA, Charles RG, Coulshed N. Acute staphylococcal endocarditis in pregnancy. Practitioner
220:619-22, 1978.
Holt S, Kahn MM, Orlans DA, Epstein EJ. Cephalothin induced neutropenia during the treatment of
bacterial endocarditis. Scottish Medical Journal 23:135-139, 1978.
Holt S, Millar JW, Heading RC, Charles RG. Spontaneous mid-oesophageal rupture. Postgraduate
Medical Journal 54:559-65, 1978.
Holt S, Samuel E. Multiple concentric ring sign in ultrasonographic diagnosis of intussusception.
Gastrointestinal Radiology 3:307-9, 1978.
Pottage A, Holt S, Ludgate S, Langlands D. 5-fluorouracil cardio- toxicity. British Medical Journal
1:547-548, 1978.
Holt S, Stewart IC, Heading RC, Macpherson AIS. Resolution of primary pneumatosis coli.
Journal of the Royal College of Surgeons of Edinburgh 23:297-9, 1978.
Holt S, Samuel E., Ultrasonic diagnosis of Gastrointestinal Lesions. British Journal of Radiology,
52: 348, 1979.
Holt S, Gilmour HM, Buist TA, Marwick K, Heading RC. High flow oxygen therapy for pneumatosis coli.
Gut 20:493-8, 1979.
Gillon J, Holt S, Sircus W. Pneumatosis coli and sigmoid volvulus: a report of 4 cases.
British Journal of Surgery 66:802-5, 1979.
Holt S, Kirkham N, Ryan WF, Coulshed N. Noonan's syndrome and cyanotic congenital heart
disease: A report of four cases and review of the literature. Acta Cardiologica (Belgium) XXXIV:167-77 ,
1979.
Holt S, Martinez AA, Coulshed N. Interatrial abscess. Postgraduate Medical Journal 55:207-9, 1979.
Holt S, Naysmith A, Reid J, Buist TA. Hazards of hepatic artery infusion of streptozocin. Scottish
Medical Journal 24:163-5, 1979.
Charles RG, Holt S, Kirkham N, Epstein EJ. Myocardial infarction and marijuana. Clinical
Toxicology 14:433-8, 1979.
Holt S, Samuel E. Grey scale ultrasound in Crohn's disease. Gut 20:590-5, 1979.
Gillon J, Tadesse K, Logan RF, Holt S, Sircus W. Breath hydrogen in pneumatosis cystoides intestinalis.
Gut 20:1008-11, 1979.
Millar JW, Holt S, Gilmour HM, Robertson DH. Vulval tuberculosis. Tubercle 60:173-6, 1979.
Holt S, Blackwell JN. Dermatitis herpetiformis and diabetes mellitus. Postgraduate Medical Journal
56:15-7, 1980.
Holt S, Heading RC, Carter DC, Prescott LF, Tothill P. Effect of gel fiber on gastric emptying and the
absorption of glucose and paracetamol. Lancet 1:636-9, 1979.
Taylor TV, Holt S, McLoughlin GP, Heading RC. A single scan technique for estimating acid output.
Gastroenterology 77:1241-4, 1979.
Reid J, Gilmore HM, Holt S. Primary nonspecific ulcer of the small intestine. Journal of the Royal
College of Surgeons of Edinburgh, 27(4):228-32, 1982.
Reid J. Holt S, Housley E, Sneddon DJ. Raynaud's phenomenon induced by sulphasalazine.
Postgraduate Medical Journal 56:106-7, 1980.
Holt S, S, MC.Dicken WN, Anderson T, Stewart IC, Heading RC. Dynamic imaging of the stomach
by real-time ultra-sound "A method for the study of gastric motility" Journal of the British Society of
Gastroenterology-GUT 21:591-601, 1980
Holt S, Stewart MH, Adam RD, Heading RC. Alcohol absorption, gastric emptying and a breathalyser.
British Journal of Clinical Pharmacology 9:205-8, 1980.
Reid J, Taylor TV, Holt S, Heading RC. Benign gastric ulceration and achlorhydria. Digestive
Diseases and Sciences 25:148-149, 1980.
Skinner HA, Holt S, Allen BA, Haakonson NH. Correlation between medical and behavioural data
in the assessment of alcoholism. Alcohol Clinical and Experimental Research 4:371-7, 1980.
Israel Y, Orrego H, Holt S, MacDonald DW, Meema HE. Identification of alcohol abuse: thoracic
fractures on routine chest X-rays as indicators of alcoholism. Alcoholism: Clinical and Experimental
Research 4:420-2, 1980.
Livshits O, Holt S, Skinner HA, Carlen P. Alcohol and male impotence. Substudy Publication,
Addiction Research Foundation, Toronto, Canada 1980.
Holt S, Stewart IC, Dixon JM, Elton RA, Taylor RV, Little K. Alcohol and the emergency service patient.
British Medical Journal 281:638-40, 1980.
Tothill P, McLoughlin GP, Holt S, Heading RC. The effect of posture on errors in gastricemptying
measurements. Physics in Medicine & Biology 25(6):1071-7, 1980.
Muhammed I, Holt S, McGloughlin GP, Taylor TV. Non-invasive estimation of duodenogastric reflux
using technetium-99m p-butyl-iminodiacetic acid. Lancet 2(8205):1162-5, 1980.
Holt S. Observations on the relations between alcohol absorption and the rate of gastric emptying.
Canadian Medical Association Journal 124(3):267-77, 1981.
Skinner HA, Holt S, Israel Y. Identification of alcohol abuse. I. Critical issues and psychosocial
indicators for a composite index. Canadian Medical Association Journal 124(9):1141-52, 1981.
Holt S, Skinner HA, Israel Y. Identification of alcohol abuse. II. Clinical and laboratory indicators.
Canadian Medical Association Journal 124(10):1279-94, 1981.
Charles R, Holt S, Kay JM, Epsein EJ, Rees JR. Myocardial ultra-structure and the development of
atrioventricular block in Kearns-Sayre syndrome. Circulation 63(1):214-9, 1981.
Holt S, Skinner HA, Confronting Alcoholism Canadian Medical Association Journal 1990, 51, 8-9.
Blackwell JN, Holt S, Heading RC. Effect of nifedipine on esophageal motility and gastric emptying.
Digestion 21(1):50-6, 1981.
Holt S, Heading RC, Clements J. Tothill P. Acetaminophen absorption and metabolism in celiac
disease and Crohn's disease. Clinical Pharmacology & Therapeutics 30(2):232-8, 1981.
Holt S, Ford MJ, Grant S, Heading RC. Abnormal gastric emptying in primary anorexia nervosa.
British Journal of Psychiatry 139:550-2, 1981.
Holt S, Taylor TV, McLoughlin GP, Heading RC, Tothill P. An evaluation of 99mTC pertechnetate
scanning for the detection of coeliac disease and Crohn's disease. European Journal of Nuclear
Medicine 6:361-4, 1981.
Holt S, Heading RC, Clement J. Effects of Dietary Fiber. Gastroenterology 80:1611, 1981.
Pacy MP, Holt S. Acute and chronic hepatitis. Medicine North America 19:1853-1964, 1982.
Holt S, Skinner HA. Confronting alcoholism. Canadian Medical Associ- ation Journal 126:351-2, 1982.
Holt S, Reid J. Taylor TV, Tothill P, Heading RC. Gastric emptying of solids in man. Gut 23(4):292-6, 1982.
Charles RG, Epstein EJ, Holt S, Coulshed N. Coronary embolism in valvular heart disease.
Quarterly Journal of Medicine 51(202):147-61, 1982.
Skinner HA, Holt S. Early intervention for alcohol problems. Journal of the Royal College of General
Practitioners 33:787-91, 1983.
Taylor TV, Holt S, Andrews PL, Heading RC. Vagotomy by chemoneurolysis: an experimenta
l study in the rat. Gut 24(2):158-60, 1983.
Holt S, Noujaim AA, Longenecker BM. Radioimmunotechnology for cancer diagnosis and treatment.
Canadian Medical Association 129, 1:18-19, 1983.
Ford MJ, Anderson JR, Gilmour HM, Holt S, Sircus W, Heading RC. Clinical spectrum of "solitary ulcer"
of the rectum. Gastroenterology 84(6):1533-40, 1983.
Styles CB, Holt S, Bowes KL, Hooper R. Esophageal transit scintigraphy - a cautionary note. Journal
of the Canadian Association of Radiologists 35:31-3, 1984.
Styles CB, Holt S, Bowes KL, Jewell L, Hoopes R. Gastroesophageal reflux and transit scintigraphy:
A comparison with esophageal biopsy in patients with heartburn. Journal of the Canadian Association
of Radiologists 35(2):124-7, 1984.
Skinner HA, Holt S, Schuller R, Ray J, Israel Y. Identification of alcohol abuse using laboratory tests
and a history of trauma. Annals of Internal Medicine 101(6):847-51, 1984.
*Rao SAS, Holt S. Ultrasound evaluation of the gastrointestinal tract. Internal Medicine for the Specialist
5:90-100, 1984.
*Mullen KD, Holt S. Nutrition and alcoholic liver disease. Medicine North America 16:1974-1984, 1984.
Holt S, Wilkinson A, Suresh MR, Mate G, Reid WB, Longenecker BM, McPherson A, Noujaim AA.
Radiolabelled peanut lectin for the scintigraphic detection of cancer. Cancer Letters 25:55-60, 1984.
Holt S, Tulip J. Hamilton D, Fields A, Cummins J, Dick C. Experimental laser photo therapy of Morris
7777 hepatoma in the rat. Hepatology 5, II:175-180, 1985.
Taylor TV, Holt S, Heading RC. Gastric emptying after anterior lesser curve seromyotomy with posterior
truncal vagotomy. British Journal of Surgery 72(8):620-2, 1985.
Holt S, Heading RC, Taylor TV, Tothill P, Forrest JA. Is gastric emptying abnormal in duodenal ulcer?
Digestive Diseases and Sciences 31(7):685-92, 1985.
*Holt S. Clinical aspects of gastrointestinal scintigraphy. Internal Medicine for the Specialists 6:2, 1985.
Styles CB, Schmidt RP, Holt S, Marion C, Chmiel RL. The detection of abscesses with diffusible tracers.
International Journal of Nuclear Medicine & Biology 12(2):145-9, 1985.
Holt S. Gastric emptying: control and measurement. Survey of Digestive Diseases 3, 4:210-229, 1985.
Holt S, Cervantes J. Wilkinson AA, Wallace JH. Measurement of gastric emptying rate in humans by
real-time ultrasound. Gastroenterology 90(4):918-23, 1986.
*Holt S, Diaz M, Eckhauser ML, Grisoni E. Acute Acalculous Chole-cystitis. Internal Medicine for the
Specialist 7, 4:128-145, 1986.
Skinner HA, Holt S, Sheu WJ, Israel Y. Clinical versus laboratory detection of alcohol abuse: the
alcohol clinical index. British Medical Journal 292(6537):1703-8, 1986.
Heading RC, Holt S,. Abnormal gastric emptying in anorexia. Dig Dis Sci 31(7):778-9, 1986.
Eckhauser ML, Persley J, Bonaminio A, Crespin J, Imbemdo AL, Holt S. Biodistribution of the
Photosensitizer Dihematoporphyrin Ether. Lasers in Medical Science 2:101-105, 1987.
Holt S, Vasudeva R. Intragastric devices for weight loss: Fact or fancy? (editorial) American Journal of
Gastroenterology 83(5):554-5, 1988.
Holt S. Tackling the alcohol problem: the case for secondary prevention. Journal of the South Carolina
Medical Association 85(12):582-4, 1989.
*Vasudeva R, Holt S, Taylor TV. Obesity: medical and surgical management. Current Opinion in
Gastroenterology 5, 6:865-869, 1989.
Holt S. Identification and intervention for alcohol abuse. Journal of the South Carolina Medical Association
85(12):554-9, 1989.
*Holt S, Taylor TV. Stomach and duodenum: Editorial Overview. Current Opinion in Gastroenterology
5, 6:777-779, 1989.
*Holt S, Howden CW. New drugs in the treatment of gastroduodenal disorders. Current Opinion in
Gastroenterology 5, 6:842-845, 1989.
*Holt S, Vasudeva R, Ramirez F, Powers R. Somatostatin and the gastro-intestinal tract: physiology
and therapeutic potential. Internal Medicine for the Specialist 11, 7:49-62, 1990.
Holt S, Colliver J, Guram M, Neal C, Verhulst SJ, Taylor TV. Measurement of gastric emptying rate in
humans: simplified scanning method. Digestive Diseases and Sciences 35, 11:1345-1351, 1990.
Holt S, Miron SD, Diaz MC, Shields R, Ingraham D, Bellon E. Scintigraphic assessment of oropharyngeal
transit in man. Digestive Diseases and Sciences 35(10):1198-1204, 1990.
Holt S. Alcohol and H2 Receptor antagonists: "Over the counter, under the table?" American Journal of
Gastroenterology 85, 5:516-517, 1990.
Taylor TV, Holt S. Anti-reflux surgery - a time for reappraisal. British Medical Journal 300(6740):1603-4, 1990.

SELECTED ABSTRACTS, PROCEEDINGS, COMMUNICATIONS:
Holt S, Cudworth AG. Insulin resistance drug continuous infusion of insulin. Lancet I:114 (letter)
Holt S. Hazards on monocomponent insulins. British Medical Journal 1:1075, 1976 (letter).
Holt S, Jones PGW. Additions to intravenous fluids. Lancet I:853, 1976 (letter).
Kirkham N, Holt S. Practolol induced nail dystrophy. Lancet 2:1137, 1976 (letter).
Holt S, Gilmour HM, Buist TAS, Heading TC. High flow oxygen therapy for pneumatosis coli.
Proceedings of the Caledonian Society of gastroenterology. Edinburgh, March 1978.
Holt S, Samuel E. Ultrasonic diagnosis of gastrointestinal lesions. Proceedings of the Joint
Meeting and 36th British Institute of Radiology Annual Congress: Scientific Exhibition, April 1978.
Holt S, Research Seminars, Department of Clinical Pharmacology, Huddinge Hospital, Huddings,
Sweden. Paracetamol disposition in patients with small intestinal mucosal disease, April 1978.
Holt S, Heading RC. Observations on the treatment of primary pneumatosis coli. Gut 19:A976, 1978.
Taylor TV, Holt S, McGloughlin GP, Heading RC. A single scan technique for estimating maximal acid
output. Gut 19:A997, 1978.
Gillon J, Tadesse K, Logan FRA, Holt S, Sircus W. Breath hydrogen in pneumatosis cystoides
intestinalis. Gut 19:A997, 1978.
Blackwell JN, Heading RC, Holt S. The effect of nifedipine on esophageal motility and gastric emptying.
Proceedings of Caldonia Society of Gastroenterology, Edinburgh, February 1979.
Holt S, Gillon J, Heading RC. Sircus W. Pneumatosis coli. Gut 10:A449, 1979.
Holt S, Heading RC, McGloughlin GP, Prescott LF. Paracetamol absorption in celiac disease and
Crohn's disease. Gut 20:1449, 1979.
Reid J, Taylor TV, Holt S, Heading RC. Benign gastric ulceration in pernicious anemia. Proceedings
of the Caledonian Society of Gastroenterology, June 1979.
Holt S, McGloughlin GP, Prescott LF, Heading RC. Gastric emptying and paracetamol absorption in
patients with small intestinal mucosal disease. Proceedings of the International Symposium on Drug
Absorption, Edinburgh, 78, 1979.
Blackwell JN, Holt S, Heading RC. Effect of nifedipine on esophageal motility. Gut 10:A919, 1979.
Anderson T, McDicken WN, Holt S, Stewart IC, Heading RC. A technique for the study of gastric motility
using real time ultrasound. Proceedings of the Eleventh Annual Meeting of the British Medical Ultrasound
Society, December 1979.
Taylor TV, Holt S. Endoscopic vagotomy, an experimental study. Proceedings of the Surgical Research
Society of Great Britain, 1980.
Kapur BM, Holt S, Black J, Orrego H. HDL-cholesterol in Alcoholics with Liver Disease. Proceedings of
the American Association for Clinical Chemistry and Canadian Society of Clinical Chemists, 1980.
Taylor TV, Holt S. Endoscopic Vagotomy. Proceedings of the Scottish Society of Experimental Medicine,
January 1980.
Stewart IC, McDicken WN, Holt S, Heading RC. Ultrasonic scanning
of the stomach. Proceedings of the Caledonian Society of Gastroenterology, 1980.
Taylor TV, Holt S. Operative intraincisional antibiotics in abdominal surgery - a controlled trial. Proceedings
of the Surgical Research Society of Edinburgh, 1980.
Holt S. Pneumatosis cystodies intestinalis in man. Proceedings of the St. Andrews Day Festival, Royal
College of Physicians of Edinburgh, December 1980.
Blackwell JN, Hannan J, Holt S, Tothill P, Heading RC. Radionuclide transit studies of the esophagus.
Gut 5, 22:A424, 1981.
Ford MJ, Anderson J, Holt S, Gilmour HM, Heading RC, Sircus W. Clinical course of solitary ulcer of the
rectum. Gut 5, 22:A443, 1981
Skinner HA, Holt S, Schuller R, Clay W, Israel Y. Alcohol use and hypertension. Annals RCPSC 16, 4:326,
June 1983.
Holt S, Longenecker BM, Noujaim AA, Terner UK. Radioimmunodetection and treatment of human colon
cancer in nude mice using a monoclanal antibody. Annals RCPSC 16, 4:328, June 1983.
Schmidt RP, Holt S, Styles CB, McGann LE, Jeske D, Lentle BC. Laboratory and animal studies using a
new technique for the labelling of autologous leukocytes with 111Indium. Annals RCPSC 16, 4:363, June 1983.
Holt S, Styles CB, Hooper R, Bowes KL, Jewell LD, Lentle BC. Combined radionuclide transit reflux
scintigraphy of the esophagus. Annals RCPSC 16, 4:365, June 1983.
Holt S, Taylor TV, McGloughlin GP. Scintigraphic studies of the stomach will TC99m pertechnetate.
Annals RCPSC 16, 4:365, June 1983.
Holt S, Tulip J, Hamilton D, Fields AL, Dick C. Experimental laser phototherapy of Morris 777 hepatoma.
Annals RCPSC 16, 4:371, June 1983.
Holt S, Terner UK, Styles CB, Longenecker BM, Noujaim AA. Radio- immunodetection of human cancer
in nude mice using monoclanal antibodies. Hybridoma 2, 2:248, 1983.
Suresh MR, Wilkinson AA, Holt S, Shysh A, Matte G, Longenecker BM, Noujaim AA. The Disposition of
Peanut Lectin in Humans, Third International Conference of Radiopharmacology, Freiburg, September
21-25, 1983.
Chmiel RL, Styles CB, Schmidt RB, Holt S, Marion G. The Detection of Abscesses with Diffusible Tracers,
Proceeding of the Society of Nuclear Medicine (Australia), 1984.
Diaz M, Holt S, Miron S, Bellon E. Deglutitive Scintigraphy. Gastroenterology, 88, 5, 13, 65, 1985.
Holt S, Taylor TV, Vasudeva R, Bonaminio A, Sharma B. Endoscopic chemoneurolysis of the vagus in
the dog. Gastrointestinal Endoscopy 32, 2:171, 1986.
Holt S, Lavery J, Miron S, Magiera C, Avello W, Robinson B, Bellon E. Is gastric emptying abnormal in
gastric ulcer? Gastroenterology 90, 2:1464, 1986.
Lavery JE, Miron S, Holt S, Bellon E. Analysis of gastric emptying data: A reappraisal. Gastroenterology
90, 2: 1843, 1986.
Durrans D, Taylor TV, Holt S. The safety and efficacy of the Mill-Rose intragastric balloon for weight loss
in the morbidly obese. Gastrointestinal Endoscopy 32, 2:171, 1986.
Eckhauser ML, Holt S, Persky J, Bonaminio A. The biodisposition of diethyl hematoporphyrin derivatives
in tumor bearing animals. Proceedings of the 1st International Symposium on Photosensitizers, Tokyo,
Japan, May 1986.
Perskey J, Eckhauser ML, Holt S, Bonaminio A. The distribution of the photosensitizer DHE in animals.
Proceedings of Surgical Society of Ohio, 1986.

Heading RC, Holt S. Abnormal gastric emptying in anorexia. Digestive Diseases and Sciences 31, 7:778,
1986.
Taylor TV, Durrans D, Holt S. The Taylor intragastric balloon device for weight loss. Digestive
Diseases and Sciences, 31, 10:560, 1986.
'Brien J, Vasudeva R, Guram M, Stapleton D, Sutherland J, Katterhagen G, Holt S. Physician intervention
in a community screening program for colon cancer. Gastroenterology, 92, 5:1556, 1987.
O'Brien J, Vasudeva R, Guram M, Stapleton D, Sutherland J, Katterhagen G, Holt S. Preferences and
characteristics of positive respondents in a community colon cancer screening program. Gastroenterology,
92, 5:1557, 1987.
Vasudeva R, Guram M, Rusky R, Neal C, Stapleton D, Colliver J, O'Brien J, Verhulst S, Holt S. Simple
scintigraphic method for assessment of gastric emptying rate. Gastroenterology, 2, 5:1681, 1987.
Stapleton D, Holt S. Symptoms and reflux events are often unrelated. American Journal of Gastroenterology,
82, 9:923, 1987.
Guram M, Vasudeva R, Stapleton R, Proksch S, Colliver J, Holt S. Interrelationships among symptoms
and esophageal tests in gastroesophageal reflux disease (GERD). American Journal of Gastroenterology,
82, 9:927, 1987.
Guram M, Vasudeva R, Neal C, Stapleton D, Colliver J, Verhulst S, Holt S. Simplified scanning method
for assessment of gastric emptying rate. American Journal of Gastroenterology, 82, 9:941, 1987.
Durrans D, Taylor TV, Holt S. The effect of the Taylor intragastric balloon device (TIB) on gastric mucosa
and acid secretion. American Journal of Gastroenterology, 81, 9:943, 1987.
Durrans D, Taylor TV, Holt S. Volume of gastric balloons for obesity treatment determines food intake.
American Journal of Gastroenterology, 82, 9:943, 1987.
Taylor TV, Blower AL, Holt S. A new device for isolated duodenal tamponade in the management of bleeding
duodenal. American Journal of Gastroenterology, 82, 9:951, 1987.
O'Brien J, Vasudeva R, Guram M, Stapleton D, Proksch S, Katterhagen G, Holt S. Risk factors, patient
investigation and staging in a community colon cancer screening program. American Journal of
Gastroenterology, 82, 9:955, 1987.
Taylor TV, Rimmer S, Holt S. Sex-related difference in patients with gallstone pancreatitis. American
Journal of Gastroenterology, 82, 9:970, 1987.
Neal C, McGuire A, Maxey R, Cull R, Snyder M, Vasudeva R, Holt S. Substantial differences in gastric
emptying data are determined by imaging protocol. Proceedings of the Society of Nuclear Medicine 35th
Annual Meeting, June 1988.
McGuire A, Neal C, Maxey R, Cull R, Snyder M, Vasudeva R, Holt S. Time zero in gastric emptying: Does
it matter? Proceedings of the Society of Nuclear Medicine 35th Annual Meeting, June 1988.
Vasudeva R, Guram M, Neal C, Taylor TV, Holt S. Measurement of segmental transit and velocity in the
human esophagus. Proceedings of the XIII International Congress of Gastroenterology and the VI
European Congress of Digestive Endoscopy, September 1988.
Blower AL, Taylor TV, Holt S. Balloon tamponade for bleeding duodenal ulcer. Proceedings of the XIII
International Congress of Gastroenterology and the VI European Congress of Digestive Endoscopy,
September 1988.
Guram M, Neal C, McGuire A, Vasudeva R, Taylor TV, Holt S. A need for standardized imaging protocol
for gastric emptying measurement. Proceedings of the XIII International Congress of Gastroenterology
and the VI European Congress of Digestive Endoscopy, September 1988.
Taylor TV,Durrans D, Vasudeva R, Marshall J, Schreiber H, Kolozsi W, Holt S. Efficacy of a new intragastric
device for weight loss in major obesity. Proceedings of the XIII International Congress of Gastroenterology
and the VI European Congress of Digestive Endoscopy, September 1988.
Smith M, Vasudeva R, Skinner HA, Holt S. Computer assessment of lifestyle in a gastroenterology (GI) clinic .
American Journal of Gastroenterology, 83, 9:1065, 1988.

Vasudeva R, Neal C, Peters J, Smith M, Holt S. A new measure of segmental transit and velocity in the
human esophagus. American Journal of Gastroenterology, 83, 9:1027, 1988.
Vasudeva R, Neal C, McGuire A, Colliver J, Guram M, Holt S. A need for standardized imaging protocol
for gastric emptying measurement. American Journal of Gastroenterology, 83, 9:1041, 1988.
Guram M, Segel N, Neal C, Vasudeva R, Holt S. Ultrasonic assessment of volume change in the stomach.
American Journal of Gastroenterology, 83, 9:1033, 1988.
Vasudeva R, Guram M, Smith M, Skinner HA, Gavin D, Taylor TV, Holt S. Supine (night time) reflux
predominates in patients with esophagitis. American Journal of Gastroenterology, 83, 9:1027, 1988.
Vasudeva R, Neal C, Peters J, Colliver J. Holt S. Radionuclide esophageal transit studies: Reproducible
or not? American Journal of Gastroenterology, 83, 9:1027, 1988.
Vasudeva R. Zaidi S, Traycoff R, Holt S. Advantage of early neurological intervention in obscure abdominal
pain. American Journal of Gastroenterology, 83, 9:1059, 1988.
Vasudeva R, Guram M, Skinner HA, Gavin D, Holt S. Simplifying the DeMeester composite score for
d iagnosis of gastroesophageal reflux (GER). American Journal of Gastroenterology, 83, 9:1027, 1988.
Abbas F, Heading RC, Gillon J, Holt S. The clinical spectrum of pneumatosis cystoides intestinalis.
American Journal of Gastroenterology, 83, 9:1042, 1988.
Abbas F, Trapp R, Lai G, Kolm P, Colliver J, Vasudeva R, Holt S. Sequential observations of symptoms
and gastroduodenal damage due to non-steroidal anti-inflammatory drugs (NSAIDS). American Journal
of Gastroenterology, 83, 9:1028, 1988.
Lai G, Smith M, Abbas F, Vasudeva R, Holt S. The role of radio-immunosorbent testing (RAST) in a
gastroenterology clinic. American Journal of Gastroenterology, 83, 9:1050, 1988.
Abbas F, Guram M, Vasudeva R, Trapp R, Holt S. Mismatch between endoscopic findings and symptoms
in patients taking non-steroidal anti-inflammatory drugs before and during treatment. Proceedings of the
American Society of Gastrointestinal Endoscopy, 1989.
Locklear G, Gilrane TB, Holt S, Glover WJ, Powers RE. Histamine may play a role in experimental pancreatic
edema in mice. Proceedings of the American Society of Gastroenterology, 1989.
Guram M, Vasudeva R, Holt S. Radionuclide esophageal transit. Proceedings of American College of
Physicians, 70th Annual Session, April 1989.
Guram M, Vasudeva R, Holt S. Gastroesophageal reflux scoring system: A controversy. Proceedings of
American College of Physicians, 70th Annual Session, April 1989.
Guram M, Smith M, Holt S. Patients tell more to a computer than a physician. Proceedings of American
College of Physicians, 70th Annual Session, April 1989.
Seabrook M, Smith M, Ingraham D, Todd M, Powers R, Holt S. Continuous esophageal pH monitoring is
reliable in routine studies in children and adults. Proceedings of the Regional Meeting of the American
College of Physicians, Asheville, NC, August 1989.
Locklear G, Bluhm C, Ingraham D, Holt S. Refractory ascites in the alcoholic: masquerading tubercle.
Proceedings of the Regional Meeting of the American College of Physicians, Asheville, NC, August 1989.
Ingraham D, Miron S, Holt S. Non-invasive scintigraphic studies of oropharyngeal dysphagia. New,
sensitive and quantitative measures? Proceedings of the Regional Meeting of the American College of
Physicians, Asheville, NC, August 1989.
Bluhm C, Bickerstaff C, Holt S. Refractory esophageal candidiasis in AIDS; emergence of aspergillus.
Proceedings of the Regional Meeting of the American College of Physicians, Asheville, NC, August 1989.
Saleeby G, Ingraham D, Bryan C, Holt S. Protracted biliary involvement in AIDS: when and how do we
intervene? Proceedings of the Regional Meeting of the American College of Physicians, Asheville, NC,
August 1989.
Guram M, Heading R, Holt S. Pneumatosis Cystoides Intestinalis. Proceedings of the Regional Meeting
of the American College of Physicians, Asheville, NC, August 1989.
Gilrane T, Glover W, Holt S, Powers R. A temporal role of neutrophils in caerulin-induced pancreatitis.
Proceedings of American Pancreatic Association, November 1989.

Brown D, Vasudeva R, Colliver J, Holt S. Relationship between symptoms and erosive esophagitis,
before and after healing? American Journal of Gastroenterology, 84, 9:1141, 1989.
Ingraham D, Miron S, Holt S. Non-invasive scintigraphic studies of oropharyngeal dysphagia: new,
sensitive and quantitative measures? American Journal of Gastroenterology, 84, 9:1144, 1989.
Karras P, Holt S, Abbas F, Smith M, Bodnarchuk G. Reliability of the single-sensor antimony pH probe.
American Journal of Gastroenterology 84, 9:1145, 1989.
Seabrook M, Smith M, Ingraham D, Todd M, Powers R, Holt S. Continuous esophageal pH monitoring is
reliable in routine studies in children and adults. American Journal of Gastroenterology, 84, 9:1149, 1989.
Ferguson G, Taylor TV, Holt S. Gastric motility in diabetic gastroparesis: evidence for decreased strength
of antral contraction. American Journal of Gastroenterology, 84, 9:1159, 1989.
Ferguson MD, Taylor TV, Holt S. Gastric motor function is inadequately assessed by gastric emptying rate
alone: more sensitive radionuclide studies. American Journal of Gastroenterology, 84, 9:1159, 1989.
Gilrane TB, Ingraham D, Bluhm C, Locklear G, Bickerstaff C, Holt S. Does antibiotic prophylaxis decrease
wound infections in percutaneous endoscopic gastrostomy?: an unresolved issue. American Journal of
Gastroenterology, 84, 9:1160, 1989.
Vasudeva R, Verhulst S, Colliver J, Skinner H, Holt S. Alcohol and smoking as determinants of dyspeptic
symptoms. American Journal of Gastroenterology, 84, 9: 1172, 1989.
Thomas PE, Taylor TV, Holt S. Are there long term metabolic or hematological consequences of
restorative proctocolectomy? American Journal of Gastroenterology, 84, 9:1198, 1989.
Vasudeva R, Verhulst S, Colliver J, Skinner HA, Holt S. Alcohol consumption, lifestyle and bowel habit: a
reappraisal. American Journal of Gastroenterology, 84, 9:1198, 1989.
Ingraham D, Locklear G, Gilrane T, Glover W, Holt S, Powers R. One reason why serum enzymes may
not consistently detect acute pancreatitis. American Journal of Gastroenterology, 84, 9:1210, 1989.
Stone R, Peveler M, Robinson M, Barden P, Holt S, Hirschowitz B, Moyer R, Humphries T, Root J,
LaMont B, Hufnagel K. Famotidine (FAM) 20 mg b.i.d. relieves symptoms associated with
gastroesophageal reflux disease (GERD) in patients with an endoscopically normal esophagus or
minimal mucosal disease. American Journal of Gastroenterology, 84, 9:1143, 1989.
Hirschowitz B, Holt S, Robinson M, Behar J, Sontag S, Berenson M, McCullough A, Humphries T,
Cagliola A. Berman R. Omeprazole (OME) is superior to placebo (PBO) in the complete relief of
heartburn and endoscopic healing in patients with reflux esophagitis (RE): U.S. Multicenter Dose
Ranging Study Results. American Journal of Gastroenterology, 84, 9:1144, 1989.
Powers RE, Grady T, Holt S, Steer ML, Saluja AK. Induction of acute pancreatitis in mice by the
administration of supramaximal doses of JMV-189. Proceedings of the International Workshop on
Pancreatic Inflammatory Disease, April 26-27, 1990.
Grady T, Glover WJ, Holt S, Powers RE. Gabexate mesylate, a protease inhibitor, blocks heterologous
desensitization in caerulein-induced pancreatitis in rats. Proceedings of the International Workshop in
Pancreatic Inflammatory Disease, April 26-27, 1990.
Powers RE, Grady T, Holt S, Steer ML, Saluka AK. Supramaximal doses of a novel CCK analogue
(JMV-180) induces acute pancreatitis in mice. Gastroenterology, 98, 5, 231A, 1990.
Gilrane TB, Glover WJ, Holt S, Granger DN, Powers RE. Edema formation parallels neutrophilia in
experimentally-induced pancreatitis. Gastroenterology, 98, 5, 217A, 1990.
Wong S, Gilrane T, Holt S. Pattern and determinants of peptic ulcer in community and veterans
administration endoscopic practice. The American Journal of Gastroenterology 85, 9:1299, 1990.
Saleeby G, Holt S. Why do patients with life threatening complications of peptic ulcer (PU) take
nonsteroidal anti-inflammatory drugs (NSAID)? The American Journal of Gastroenterology 85, 9:1294,
1990.
Saleeby G, Holt S. An alarming association between nonsteroidal anti-inflammatory drug (NSAID)
use and complicated peptic ulcer (PU). The American Journal of Gastroenterology, 85, 9:1294, 1990.
Seabrook M, Amarnath R, Amarnath U, Leonor M, Rentz S, Holt S. Feeding and luminal pH: Implications
for pH monitoring in infants. The American Journal of Gastroenterology 85, 9:1295, 1990.
Seabrook M. Holt S. What happens to patients with chest pain (CP) and normal coronary arteriography
(NC) in community practice? The American Journal of Gastroenterology 85, 9:1295, 1990.
Seabrook M, Amarnath R, Marsh D, Amarnath U, Pai S, Holt S. Intragastric pH in premature infants in
an intermediate care unit. The American Journal of Gastroenterology 85, 9:1295, 1990.
Bluhm C, Taylor V, Holt S. Long term observations of the outcome of antireflux surgery (ARS) in
community practice. The American Journal of Gastroenterology 85, 9:1217, 1990.
Vasudeva R, Verhulst S, Colliver J, Skinner H, Holt S. Are alcohol use, smoking, and peptic ulcer
disease interrelated? The American Journal of Gastroenterology 85, 9:1298, 1990.
Holt S, Zhu Z, Grady T, Powers R. Is omeprazole genotoxic? The American Journal of Gastroenterology
85, 9:1291, 1990.
Gilrane TB, Zhu ZH, Grady T, Hightower JA, Holt S, Grisham MB, Granger DN, Powers RE.
Myeloperoxidase activity as a measure of the intensity of pancreatic inflammation. Pancreas 5:708, 1990.
Powers RE, Zhu ZH, Grady T, Hightower JA, Holt S, Grisham MB, Granger DN, Gilrane TB.
Myeloperoxidase distinguishes physical from physiological damage in bile salt pancreatitis in
live and dead rats. Pancreas 5:726, 1990.
Seabrook M, Amarnath RP, Amarnath U, Marsh D, Pai S, McKay J, Holt S. 24 hour intragastric acid
profiles in fed and fasted premature infants. Gastroenterology (in press), 1991.
Guram M, Holt S. Are ethanol-H2 receptor antagonist (H2RA) interactions "relevant"?
Gastroenterology (in press), 1991.
Saleeby G, Holt L. Holt S. Pattern and prevalence of non-steroidal anti-inflammatory drug (NSAID) use
in complicated peptic ulcer disease (CPUD). Gastroenterology (in press), 1991.
Zhu ZH, Grady T, Gilrante TB, Purewal M, Holt S, Powers RE. A somatostatin analogue inhibits pancreatitis,
but not pancreatic neutrophil infiltration, in a rat model. South Carolina Academy of Science, April, 1991.
Saleeby G, Holt S, Holt L, Eleazor P. Pattern and prevalence of non-steroidal anti-inflammatory drug use in
elderly patients with complicated peptic ulcer disease. Clinical Research 39, 2:594A, 1991.
Taylor TV, Holt S, Pullan BR. Tissue necrosis induced by direct electrical current (DEC): therapeutic
potential in the gastrointestinal (GI) tract. The American Journal of Gastroenterology 86, 9:1377, 1991.
Irshad M, Gopal A, Saleeby G, Holt S, Howden CW. NSAID use as a contributory factor in lower
GI tract bleeding. The American Journal of Gastroenterology 86, 9:1312, 1991.
Guram M, Holt S, Neal C, Colliver J, Verhulst S, Abbas F, Smith M. Towards the standardization of
scintigraphic measurements of gastric emptying rate. The American Journal of Gastroenterology 86, 9:1312, 1991.
Guram M, Todd M, Popp J, Holt S. Stomal Complications of replacement gastrostomy buttons.
The American Journal of Gastroenterology 86, 9:1370, 1991.
Naseer K. Amarnath R, Holt S. Prevalence of Helicobacter pylori (Hp) in children undergoing upper
GI endoscopy. The American Journal of Gastroenterology 86, 9:1317, 1991.
Seabrook M, Naseer K, Howden CW, Holt S. Is radio-isotope scanning helpful in establishing a
cause of lower GI tract bleeding? The American Journal of Gastroenterology 86, 9:1376, 1991.
Gopal A, Todd M, Irshad M, Howden CW, Holt S. Prevalence of NSAID use among patients
undergoing routine upper GI endoscopy. The American Journal of Gastroenterology 86, 9:1312, 1991.
Saleeby G, Howden CW, Holt S. Over the counter (OTC) non-steroidal anti-inflammatory drug (NSAID)
use may be an important determinant of complicated peptic ulcer disease (CPUD). The American
Journal of Gastroenterology 86, 9: 1375, 1991.
Howden CW, Saleeby G, Holt L, Holt S. Follow-up of patients with NSAID-related complicated peptic
ulcer disease (CPUD). The American Journal of Gastroenterology 86, 9: 1313, 1991.

Holt S, Guram M, Howden CW. Evidence for an interaction between alcohol and certain H2-receptor
antagonists (H2RA). Proceedings of the Annual Meeting of the British Society of Gastroenterology, 1991.
Saleeby G, Howden CW, Holt S. Patient understanding of NSAIDs and ulcer complications: a need
for improvement. Proceedings of the Annual Meeting of the British Society of Gastroenterology, 1991.
Rigoglioso V, Mainero M, Baddoura W, Holt S. Nonsteroidal Anti-Inflammatory Drug (NSAID) Use and
Lower Gastrointestinal Bleeding (GIB). Proceedings of the New Jersey Chapter of the American College
of Physicians, October 1991.
Tempera P, Tamimi O, Holt S. Is Radioisotope Scanning Valuable in the Diagnosis of Gastrointestina
l Bleeding? Proceedings of the New Jersey Chapter of the American College of Physicians, October, 1991.
Rigoglioso V, DePasquale J, Fedida A, Guram M, Holt S. Blind Esophageal Brushing is an Alternative EGD
for the Detection of Esophageal Infection in AIDS. Proceedings of the American Society for Gastrointestinal
Endoscopy, 1992.
Gorodokin G, Grosman I, Holt L, Holt S. Over-the-counter H2-receptor antagonists: attitudes and knowledge.
Proceedings of the World Congress of Gastroenterology in Los Angeles, 1994.
Peddanna N, Holt S, Verma RS. Studies on the molecular genetics of colorectal cancer. Proceedings of
the World Congress of Gastroenterology in Los Angeles, 1994.
Gorodokin G, Grosman I, Holt L, Bhat K, Holt S. Probing perceptions of dyspepsia. Proceedings of the
World Congress of Gastroenterology in Los Angeles, 1994.
Mancino L, Mendis R, Chandramouly B, Holt S. Duodenogastric reflux (DGR) during cholescintigraphy is
a marker of biliary tract disease. Proceedings of the World Congress of Gastroenterology in Los Angeles, 1994.
Mendis R, Chandramouly B., Holt S. Scintigraphic detection of small bowel abnormalities with DISIDA:
an important noninvasive diagnostic option. Proceedings of the World Congress of Gastroenterology in
Los Angeles, 1994.
Mancino L, Chandramouly B, Grosman I, Holt S. Biliary duct transit may be independent of gallbladder filling.
Proceedings of the World Congress of Gastroenterology in Los Angeles, 1994.
Prabhu V, Gorodokin G, Holt S. Does acid neutralizing capacity of antacids make much of a difference
in duodenal ulcer healing? Proceedings of the World Congress of Gastroenterology in Los Angeles, 1994.
Brown J, Guram M, Holt S. Variable expression and function of gastric alcohol dehydrogenase (ADH).
Proceedings of the World Congress of Gastroenterology in Los Angeles, 1994.
Taylor TV, Holt S, Pullan B, Jones JW. Ablation of neoplasia bt direct electrical current. Proceedings of
the World Congress of Gastroenterology in Los Angeles, 1994.
Taylor TV, Baguneid MS, Richman BW, Jones JW, Beall AC, Holt S. Quality of life after restorative
proctocolectomy with ileal pouch formation. Proceedings of the World Congress of Gastroenterology in
Los Angeles, 1994.
Mancino L, Grosman I, Chandramouly B, Holt S. Potential pitfalls in the use of gallium-67 as a measure
of liver or pulmonary disease in the acquired immunodeficiency syndrome (AIDS). Proceedings of the
World Congress of Gastroenterology in Los Angeles, 1994.
Peddanna N, Holt S, Verma RS, Observations on the Genetics of Gastric Cancer American Journal of
Gastroeneterology 1995
Pedanna N, Rezk G, Holt S, Thromboembolism in Crohns Disease American Journal of Gastroenterology 1995
Holt S, Peddanna N, Antisecretory Drugs and Gastric Cancer International Journal of Oncology 1995
Peddanna N, Holt S, Verma RS, The Genetics of Colorectal Cancer. American Journal of Gastroenterology 1996

Eleonore Blaurock-Busch PhD

1964 - Druggists licence, Nuremberg, Germany
1968-72 Analytical Chemist, 3M Research Laboratory, St. Paul, Minnesota
1972-75 Studies Colorado University and Donsbach University
1975 PhD, Human Nutrition, Donsbach University
1975 - present Founder, Research Director, Micro Trace Minerals, Germany
1984 -2001 Director & President, Trace Minerals International, Boulder, Colorado
1986 -2001 Laboratory Director, Trace Minerals International
1986- 2001 License, Metal Toxicology, Colorado Department of Public Health and Environment;
CLIA (Clinical Laboratory Improvement Amendments) and EPA (Environmental Protection Agency) certification
2001-2005 Assistant Director, King James Medical Laboratory, Cleveland, OH
Scientific Advisor, International Board of Clinical Metal Toxicology
2002- Consultant, Synlab Medical Laboratory Group, Germany
2005- Scientific Advisor, German Medical Association for Chelation

Member:
American Chemical Society, the Bioanalyst Society and other professional organisations
She is a founding member and co-chairman of the International Association of Trace Element
Research and Cancer, and organizer of the first East-West World Congress on Trace Element and Cancer,
held in Beijing, China in 1996.

She has lectured worldwide at various universities and learning institutions, and was a frequent guest
speaker at radio and TV shows in the US, Germany and elsewhere.
She was instrumental in environmental and laboratory research projects in metal toxicology, including
epidemiological studies that evaluated the toxic burden of people of all ages of various countries.
She published several books in German and English, and hundreds of articles that were published in
various languages around the world. Her textbook Minerals and Trace Element Analysis, Laboratory and
Clinical Applications has been utilized at Bejing Medical University and other colleges